FGF21 + SIRT1 gene therapy has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Nov 10, 2026: “Combination gene therapy extended lifespan in aged obese mice”.
1 paper studies it3 findingsUpdated
1 new paper in 30 daysSee all 1 papers on FGF21 + SIRT1 gene therapy
The findings reach mice, none yet in people. 1 lab.
None of its findings points the other way.
Studies of FGF21 + SIRT1 gene therapy measured 3 outcomes: muscle function, obesity and lifespan.
Muscle function
upin mice1
FGF21 + SIRT1 gene therapy improves muscle function in mice (obese mice).
“The combination therapy of co.hFGF21 and co.hSIRT1 resulted in improved muscle function and quality.”
Animalsobese micemusclesingle dose70 weeks
Combination gene therapy extended lifespan in aged obese mice
Molecular therapy. Nucleic acids
Obesity
downin mice1
FGF21 + SIRT1 gene therapy decreases obesity in mice (obese mice) (∼33% reduction).
“these vectors effectively reduced obesity by ∼33%, improved the metabolic profile and alleviated hepatic steatosis and cardiac hypertrophy.”
Animalsobese micesingle dose70 weeks
Combination gene therapy extended lifespan in aged obese mice
Molecular therapy. Nucleic acids
Lifespan
upin mice1
FGF21 + SIRT1 gene therapy extends lifespan in mice (obese mice; compared with vector-control animals) (+60% lifespan versus vector control).
“the combinatorial gene therapy increased lifespan by 60% when compared to vector-control animals”
Animalsobese mice; compared with vector-control animalsAAV8 and AAVrh10 vectors encoding codon-optimized human FGF21 and SIRT1single dose70 weeks
Combination gene therapy extended lifespan in aged obese mice
Molecular therapy. Nucleic acids
Over 70 weeks of follow-up, aged obese mice given the combination had a 60% increase in lifespan compared with mice given control viral carriers.Over 70 weeks of follow-up, aged obese mice given the combination had a 60% increase in lifespan compared with mice given control viral carriers.