Fcrn antagonists

1. Fcrn antagonists decrease insulin resistance in humans.

   “Notably, FcRn antagonists can reverse insulin resistance, while restoration of IgG sialylation using sialic acid precursors improves function without depleting antibodies.”

   Review

   Temporal dynamics of IgG-mediated immunometabolic dysfunction: from acute obesity to chronic aging

   Frontiers in immunology·4 Dec 2025

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