Falls

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Humans2

Associations

Dementia symptom onset

upin humans1HR 21.3

1 study

Falls raise the risk of dementia symptom onset in humans (HR = 21.3, p < 0.001).
“participants in the Preclinical AD+Fall+ group had the highest hazard ratio (HR) for progression to CDR 1 (HR = 21.3, p < 0.001)”
Humansamyloid PET positive with fallsmedian 10 yearsn = 21
Falls, amyloid positivity, and dementia symptom onset
AAIC 2025 abstract26 Dec 2025

Whole-brain gray matter volume

downin humans1

1 study

Falls are associated with whole-brain gray matter volume in humans (β = −1526.601, p = 0.036).
“Those experienced single falls demonstrated reduced whole‐brain gray matter volume (β = −1526.601, p = 0.036)”
Humanssingle falls
Associations of falls and genetic risk with dementia risk: a prospective cohort study from UK biobank
AAIC 2025 abstract23 Dec 2025