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Weight loss + exercise

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Foundation for Physical Therapy and 6 more
  • Human trial1

Outcomes

4

Bone mineral density at the hip

downin humans1

1 study

  1. Weight loss + exercise decreases bone mineral density at the hip in humans (1% vs 3% reduction).

    “Lean body mass and bone mineral density at the hip decreased less in the diet-exercise group than in the diet group (reductions of 3% and 1%, respectively, in the diet-exercise group vs. reductions of 5% and 3%, respectively, in the diet group; P<0.05 for both comparisons).”

    Human trialobesity1-yearn = 107

    Weight loss, exercise, or both and physical function in obese older adults

    The New England journal of medicine31 Mar 2011

More on Bone mineral density at the hip

Body weight

downin humans1−9%

1 study

  1. Weight loss + exercise decreases body weight in humans (-9%).

    “Body weight decreased by 10% in the diet group and by 9% in the diet-exercise group, but did not decrease in the exercise group or the control group (P<0.001).”

    Human trialobesity1-yearn = 107

    Weight loss, exercise, or both and physical function in obese older adults

    The New England journal of medicine31 Mar 2011

More on Body weight

Peak oxygen consumption

upin humans1

1 study

  1. Weight loss + exercise increases peak oxygen consumption in humans (17% vs. 10% and 8%).

    “peak oxygen consumption improved more in the diet-exercise group than in the diet group or the exercise group (increases of 17% vs. 10% and 8%, respectively; P<0.001)”

    Human trialobesity1-yearn = 107

    Weight loss, exercise, or both and physical function in obese older adults

    The New England journal of medicine31 Mar 2011

Physical status

upin humans1

1 study

  1. Weight loss + exercise improves physical status in humans (21% vs. 12% and 15%).

    “the score on the Physical Performance Test, in which higher scores indicate better physical status, increased more in the diet-exercise group than in the diet group or the exercise group”

    Human trialobesity1-yearn = 107

    Weight loss, exercise, or both and physical function in obese older adults

    The New England journal of medicine31 Mar 2011

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