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ESI1

Intervention

1 paper3 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development and 7 more
  • Animals1

Outcomes

3

Cognitive function

upin mice1

1 study

  1. ESI1 improves cognitive function in mice.

    “ESI1 treatment lengthened myelin sheaths in human iPSC-derived organoids and augmented (re)myelination in aged mice while reversing age-related cognitive decline.”

    Animalsage-related cognitive decline

    Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration

    Cell2 May 2024

(re)myelination

upin mice1

1 study

  1. ESI1 increases (re)myelination in mice.

    “ESI1 treatment lengthened myelin sheaths in human iPSC-derived organoids and augmented (re)myelination in aged mice while reversing age-related cognitive decline.”

    Animals

    Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration

    Cell2 May 2024

Myelin sheath length

upin human cells1

1 study

  1. ESI1 increases myelin sheath length in human cells.

    “ESI1 treatment lengthened myelin sheaths in human iPSC-derived organoids”

    CellsiPSC-derived organoid

    Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration

    Cell2 May 2024

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