Entinostat

Intervention1 paper3 findingsPubChem 4261ChEBI 132082

Animals1

Outcomes

3

Microglial density

downin mice1Very low certainty

1 study

Entinostat decreases microglial density in mice.
AnimalsAPP/PS1 mice30 days
Histone Deacetylase Inhibitors Improve Memory Function and Decrease Neuropathology in APP/PS1 Mice · Research square · 26 Aug 2026 · Preprint

Microglial density →

Amyloid plaque burden

downin mice1Very low certainty

1 study

Entinostat decreases amyloid plaque burden in mice.
AnimalsAPP/PS1 micehippocampus and PFC30 days
Histone Deacetylase Inhibitors Improve Memory Function and Decrease Neuropathology in APP/PS1 Mice · Research square · 26 Aug 2026 · Preprint

Amyloid plaque burden →

Cognitive function

upin mice1Very low certainty

1 study

Entinostat improves cognitive function in mice.
AnimalsAPP/PS1 mice30 days
Histone Deacetylase Inhibitors Improve Memory Function and Decrease Neuropathology in APP/PS1 Mice · Research square · 26 Aug 2026 · Preprint

Latest

1

Research SquareAnimalsPreprint3 Sep

Histone Deacetylase Inhibitors Improve Memory Function and Decrease Neuropathology in APP/PS1 Mice