Enhancefitness

4 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Human trial2
In silico1

Outcomes

Physical function

upin humans1

1 study

Enhancefitness improves physical function in humans.
“Enhance®Fitness (EF) – a long-standing, evidence-based, low-cost group exercise and falls prevention program with broad adoption across community and health system settings in the U.S. – improves physical performance”
Review
Adapting Enhance®Fitness for People Living With Dementia and their Care Partners through a RE-AIM Lens
GSA 2025 abstract31 Dec 2025

Depression

upin humans1

1 study

Enhancefitness increases depression in humans.
“worse depression scores”
Human trialin completers8 weeksn = 4
ENHANCEFITNESS FOR ADULTS WITH MEMORY LOSS AND CARE PARTNERS: A PILOT
GSA 2024 abstract31 Dec 2024