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Engineered multifunctional conductive hydrogel loaded with delta-amyrenone

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

2

Cardiac function

upin mice1upin pigs1

1 study

  1. Engineered multifunctional conductive hydrogel loaded with delta-amyrenone improves cardiac function in pigs.

    “In aged mouse and Bama minipig MIR models, this strategy improves structural, functional, and electrophysiological outcomes, supporting translational potential.”

    Animalsin aged mouse and Bama minipig MIR modelsheart

    Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid-Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)21 Oct 2025

  2. Engineered multifunctional conductive hydrogel loaded with delta-amyrenone improves cardiac function in mice.

    “In aged mouse and Bama minipig MIR models, this strategy improves structural, functional, and electrophysiological outcomes, supporting translational potential.”

    Animalsin aged mouse and Bama minipig MIR modelsheart

    Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid-Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)21 Oct 2025

Mitochondrial damage

downin mice1

1 study

  1. Engineered multifunctional conductive hydrogel loaded with delta-amyrenone decreases mitochondrial damage in mice.

    “Loaded with δAe, this single-injection hydrogel provides controlled release, alleviates cuproptosis-related mitochondrial injury”

    Animalsmyocardial ischemia-reperfusionheart

    Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid-Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)21 Oct 2025

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