Embryonic stem cell-derived extracellular vesicles
2 papers study it4 findings
- 2 independent labs in 2 countries
- Funders: Japan Student Services Organization and 5 more
- Animals1
- Cells1
Outcomes
3Cellular senescence
downin cells1downin mouse cells1
2 studies
Cellular senescence
downin cells1downin mouse cells1
Embryonic stem cell-derived extracellular vesicles decrease cellular senescence in cells.
“identify a signaling pathway essential for EVs shed by ESCs to potently block fibroblasts and astrocytes from undergoing senescence.”
Cells
The Journal of biological chemistryOct 14, 2025
Embryonic stem cell-derived extracellular vesicles inhibit cellular senescence in mouse cells.
“Our findings demonstrate that ESC-EVs treatment can rejuvenate senescence both in vitro and in vivo”
Cellssenescent cells in vitro
Bioactive materialsJul 1, 2023
Cellular lifespan
upin cells1
1 study
Cellular lifespan
upin cells1
Embryonic stem cell-derived extracellular vesicles increase cellular lifespan in cells.
“These findings define a signaling pathway used by ESC-derived EVs to extend cellular lifespan”
Cells
The Journal of biological chemistryOct 14, 2025
Pathological age-related phenotypes
downin mice1
1 study
Pathological age-related phenotypes
downin mice1
Embryonic stem cell-derived extracellular vesicles decrease pathological age-related phenotypes in mice.
“The results showed that ESC-EVs successfully ameliorated the pathological age-related phenotypes and rescued the transcriptome profile of aged mice.”
Animalsin aged mice
Bioactive materialsJul 1, 2023
Latest
The Journal of Biological Chemistry
Embryonic stem cell-derived extracellular vesicles delay cellular senescence by inhibiting oxidative stress
Experiments in cellsInterventions
Bioactive Materials
Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice
Experiments in miceInterventions