Edetic acid

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 2 more
  • Animals1

Outcomes

3

Calcium deposits

downin Rodentia1

1 study
  1. Edetic acid decreases calcium deposits in Rodentia.

    “EDTA chelation therapy removes calcium deposits from arteries in the CKD model”

    Reviewin CKD modelarteries

    Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in chronic kidney disorder induced vascular calcification

    International journal of immunopathology and pharmacology15 Dec 2025

More on Calcium deposits

NLRP3 inflammasome

downin Rodentia1

1 study
  1. Edetic acid inhibits NLRP3 inflammasome in Rodentia.

    “acts as senomorphic by decreasing NLRP3 inflammasome formation”

    Animalsin calcified aorta in rodent model of CKDcalcified aorta

    Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in chronic kidney disorder induced vascular calcification

    International journal of immunopathology and pharmacology15 Dec 2025

More on NLRP3 inflammasome

SA-β-gal positive senescent cells

downin Rodentia1

1 study
  1. Edetic acid decreases SA-β-gal positive senescent cells in Rodentia.

    “targeted chelation therapy with EDTA NPs decreases the percentage of SA-β-gal positive senescent cells in the calcified aorta”

    Animalsin calcified aorta in rodent model of CKDcalcified aorta

    Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in chronic kidney disorder induced vascular calcification

    International journal of immunopathology and pharmacology15 Dec 2025

More on SA-β-gal positive senescent cells

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