Duloxetine + exercise
Duloxetine + exercise has been studied in 1 paper since 2025: 1 trial in people; 1 in the past year. The newest paper, Dec 31, 2025: “Duloxetine Plus Exercise for Knee Osteoarthritis: Targeting Pain and Depression Using Combined Treatment”.
1 paper studies it4 findingsUpdated
“KOOS pain scores increased, indicating less pain (+14.2, 95% CI [6.5, 21.9], d = 0.95)”
None of its findings points the other way.
- 1 lab in 1 country
- Human trial1
What did studies of Duloxetine + exercise find?
4Studies of Duloxetine + exercise measured 4 outcomes; the most studied are chair stands (1 study), 6-minute walk distance (1) and depressive symptoms (1).
Chair stands
upin humans1
1 study
Chair stands
upin humans1
Duloxetine + exercise improves chair stands in humans (+1.8 repetitions, 95% CI [0.7, 2.8], d = 0.88).
“Chair Stands = +1.8 repetitions, 95% CI [0.7, 2.8], d = 0.88”
Human trialsymptomatic KOA and mild to severe depressive symptoms12-week
GSA 2025 abstract
6-minute walk distance
upin humans1
1 study
6-minute walk distance
upin humans1
Duloxetine + exercise improves 6-minute walk distance in humans (+130 ft, 95% CI [56.7, 204.1], d = 0.91).
“6MWD = +130 ft, 95% CI [56.7, 204.1], d = 0.91”
Human trialsymptomatic KOA and mild to severe depressive symptoms12-week
GSA 2025 abstract
Depressive symptoms
downin humans1
1 study
Depressive symptoms
downin humans1
Duloxetine + exercise decreases depressive symptoms in humans (−5.5, 95% CI [−9.0, −2.0], d = 0.81).
“HAM-D scores decreased, implying fewer depressive symptoms (−5.5, 95% CI [−9.0, −2.0], d = 0.81)”
Human trialsymptomatic KOA and mild to severe depressive symptoms12-week
GSA 2025 abstract
Pain
downin humans1
1 study
Pain
downin humans1
Duloxetine + exercise decreases pain in humans (+14.2, 95% CI [6.5, 21.9], d = 0.95).
“KOOS pain scores increased, indicating less pain (+14.2, 95% CI [6.5, 21.9], d = 0.95)”
Human trialsymptomatic KOA and mild to severe depressive symptoms12-week
GSA 2025 abstract