Diphtheria toxin A
Diphtheria toxin A has been studied in 1 paper since 2022: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Sep 2, 2022: “Constitutive bone marrow adipocytes suppress local bone formation”.
1 paper studies it4 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Funders: American Diabetes Association and 8 more
- Animals1
What did studies of Diphtheria toxin A find?
4Studies of Diphtheria toxin A measured 4 outcomes; the most studied are bone-healing process (1 study), bone loss (1) and bone mass (1).
Bone-healing process
upin mice1
1 study
Bone-healing process
upin mice1
Diphtheria toxin A improves bone-healing process in mice.
“it facilitates the bone-healing process after fracture.”
AnimalsBMAd depletion
Constitutive bone marrow adipocytes suppress local bone formation
JCI insight
Bone loss
downin mice1
1 study
Bone loss
downin mice1
Diphtheria toxin A protects against bone loss in mice.
“Augmented bone formation with BMAd depletion protects mice from bone loss induced by caloric restriction or ovariectomy”
AnimalsBMAd depletion
Constitutive bone marrow adipocytes suppress local bone formation
JCI insight
Bone mass
upin mice1
1 study
Bone mass
upin mice1
Diphtheria toxin A increases bone mass in mice.
“increased bone mass in BMAd-enriched locations, including the distal tibiae and caudal vertebrae. Elevated bone mass appears to be secondary to enhanced endosteal bone formation”
AnimalsDTA-induced loss of BMAdsdistal tibiae and caudal vertebrae
Constitutive bone marrow adipocytes suppress local bone formation
JCI insight
Hematopoietic stem and progenitor cells
downin mice1
1 study
Hematopoietic stem and progenitor cells
downin mice1
Diphtheria toxin A decreases hematopoietic stem and progenitor cells in mice.
“DTA-induced loss of BMAds results in decreased hematopoietic stem and progenitor cell numbers”
AnimalsDTA-induced loss of BMAdsbone marrow
Constitutive bone marrow adipocytes suppress local bone formation
JCI insight