Difficulty staying asleep

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Humans2

Outcomes

Cognitive decline

no changein humans1

1 study

Difficulty staying asleep has no effect on cognitive decline in humans.
“Compared to participants with no sleep problems, participants with the other sleep problem trends did not have greater decline in cognition in unadjusted or adjusted models.”
Humansn = 437
Association Between Self-Reported Sleep Problems and Cognitive Decline: A Two-Wave Prospective Study
GSA 2025 abstract31 Dec 2025

Associations

Cognitive impairment

downin humans1RR 0.831

1 study

Difficulty staying asleep lowers the risk of cognitive impairment in humans (RR = 0.831, 95% CI 0.720∼0.959).
“Difficulty staying asleep >=3 times /week was associated with lower risk of cognitive impairment in the 80‐90 age group (RR = 0.831, 95% CI 0.720∼0.959, p = 0.011).”
Humans>=3 times /week
Subjective Sleep Characteristics and Cognitive Impairment from Ages 60 to 90+: A Pooled Analysis of Four Prospective Cohorts
AAIC 2025 abstract25 Dec 2025