Excessive daytime sleepiness

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Humans3

Outcomes

Cognitive function

downin humans1

1 study

Excessive daytime sleepiness impairs cognitive function in humans (β = ‐0.050, 95% CI: ‐0.099 to ‐0.002).
“Higher ESS scores were significantly associated with reduced baseline MMSE scores (β = ‐0.050, 95% CI: ‐0.099 to ‐0.002; p = 0.041)”
Humans10 years
Excessive Daytime Sleepiness is associated with Incident Dementia in Community‐Dwelling Older Adults: A 10‐year Longitudinal Study
AAIC 2025 abstract23 Dec 2025

Associations

Dementia

upin humans1HR 2.02

1 study

Excessive daytime sleepiness raises the risk of dementia in humans (HR = 2.02, 95% CI: 1.06‐3.83).
“Baseline EDS was associated with an elevated risk of incident dementia (hazard ratio [HR] = 2.02, 95% CI: 1.06‐3.83; p = 0.032)”
Humansadjusted by age, sex and education years10 yearsn = 618
Excessive Daytime Sleepiness is associated with Incident Dementia in Community‐Dwelling Older Adults: A 10‐year Longitudinal Study
AAIC 2025 abstract23 Dec 2025