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Dietary valine restriction

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 5 more
  • Animals1

Outcomes

2

Metabolic health

upin mice1

1 study

  1. Dietary valine restriction improves metabolic health in mice.

    “restriction of isoleucine and valine, but not leucine, promotes metabolic health.”

    Animalsin 3xTg mice

    Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice

    bioRxiv : the preprint server for biology26 Jul 2025Preprint

Cognitive function

upin mice1

1 study

  1. Dietary valine restriction improves cognitive function in mice.

    “restricting valine had the greatest cognitive benefits in females.”

    Animalsfemales

    Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice

    bioRxiv : the preprint server for biology26 Jul 2025Preprint

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