Dietary macronutrient composition

1. Dietary macronutrient composition shortens lifespan in flies (1:1 or lower).

   “High PC ratios (1:1 or lower) are best for adult body mass, male reproduction, and larval developmental time but worst for lifespan”

   Reviewhigh protein-to-carbohydrate ratio

   Nutritional Trade-Offs in Drosophila melanogaster

   Biology·Apr 7, 2025

2. Dietary macronutrient composition extends lifespan in flies (1:8 or higher).

   “Low PC ratios (1:8 or higher) are best for lifespan”

   Reviewlow protein-to-carbohydrate ratio

   Nutritional Trade-Offs in Drosophila melanogaster

   Biology·Apr 7, 2025

1. Dietary macronutrient composition impairs reproduction in flies (1:8 or higher).

   “Low PC ratios (1:8 or higher) are best for lifespan but worst for growth or reproductive traits”

   Reviewlow protein-to-carbohydrate ratio

   Nutritional Trade-Offs in Drosophila melanogaster

   Biology·Apr 7, 2025

1. Dietary macronutrient composition is associated with telomere length in humans (7.7 years of slower biological aging).

   “Diets lower in protein (5-10%), higher in carbohydrates (75%), and lower in fat (15-20%) are associated with the longest LTL corresponding to 7.7 years of slower biological aging.”

   Humanslower in protein (5-10%), higher in carbohydrates (75%), and lower in fat (15-20%)n = 4,130

   The Relationship between Dietary Macronutrient Composition and Telomere Length Among US Adults

   Advanced biology·Jan 16, 2024

More on Telomere length

1. Dietary macronutrient composition is associated with microbiota composition in flies.

   “relative macronutrient levels not only influence the host, but also have a profound impact on microbiota composition.”

   Model organismscompletely defined diet

   Glucose modulates Drosophila longevity and immunity independent of the microbiota

   Biology open·Jan 21, 2016

More on Microbiota composition