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Deworming

Deworming has been studied in 3 papers since 2024: 2 observational studies in people, 1 in animals. The newest paper, Aug 26, 2025: “Early-life infectious disease exposure, the "hygiene hypothesis," and lifespan: Evidence from hookworm disease”.

Exposure

3 papers study it3 findingsUpdated

“Findings show deworming before age five leads to 2.5 additional months of life in a large sample of adult death records.”
Early-life infectious disease exposure, the "hygiene hypothesis," and lifespan: Evidence from hookworm diseaseProceedings of the National Academy of Sciences of the United States of America2025doi:10.1073/pnas.2504265122

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: Institut National de la Santé et de la Recherche Médicale and 3 more
  • 1 of 3 findings with company ties
  • Humans2
  • Animals1

What did studies of Deworming find?

2

Studies of Deworming measured 2 outcomes; the most studied are lifespan (2 studies) and frailty (1).

Lifespan

upin humans2

2 studies

  1. Deworming extends lifespan in humans (+2.5 months of life).

    “Findings show deworming before age five leads to 2.5 additional months of life in a large sample of adult death records.”

    HumansChildhood hookworm exposureDecades later

    Early-life infectious disease exposure, the "hygiene hypothesis," and lifespan: Evidence from hookworm disease

    Proceedings of the National Academy of Sciences of the United States of America

  2. Deworming extends lifespan in humans (2.5 additional months of life).

    “de-worming before age five leads to 2.5 additional months of life in a sample of adult mortality”

    Humans

    Early-life infectious disease exposure, the 'hygiene hypothesis', and lifespan: evidence from hookworm

    medRxiv : the preprint server for health sciencesPreprint

Frailty

downin dogs1

1 study

  1. Deworming decreases frailty in dogs.

    “In the statistical analysis, older age of the dog, lower owner attachment score, lack of regular deworming, and a disparity in extraversion between owner and dog were identified as contributing factors to frailty.”

    Animalssenior pet dogsn = 74

    Exploring frailty in apparently healthy senior dogs: a cross-sectional study

    BMC veterinary research

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