AgingResearch.NewsJoin free

DCAS9-NUCLEOLIN

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Cells1

Outcomes

3

Stem cell differentiation

downin cells1

1 study

  1. DCAS9-NUCLEOLIN inhibits stem cell differentiation in cells.

    “specifically stabilize G4s in the promoter of oncogene MYC and muscle-associated gene Itga7 as well as telomere G4s, leading to cell proliferation arrest, inhibition of myoblast differentiation”

    Cellstargeting Itga7 promoter G4s

    Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands

    Nature cell biologyJul 3, 2024

More on Stem cell differentiation

Cell proliferation

downin cells1

1 study

  1. DCAS9-NUCLEOLIN inhibits cell proliferation in cells.

    “fusion of nucleolin with a catalytically inactive Cas9 can specifically stabilize G4s in the promoter of oncogene MYC and muscle-associated gene Itga7 as well as telomere G4s, leading to cell proliferation arrest”

    Cellstargeting MYC promoter G4s

    Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands

    Nature cell biologyJul 3, 2024

Cellular senescence

upin cells1

1 study

  1. DCAS9-NUCLEOLIN induces cellular senescence in cells.

    “fusion of nucleolin with a catalytically inactive Cas9 can specifically stabilize G4s in the promoter of oncogene MYC and muscle-associated gene Itga7 as well as telomere G4s, leading to cell proliferation arrest, inhibition of myoblast differentiation and cell senescence, respectively.”

    Cellstargeting telomere G4s

    Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands

    Nature cell biologyJul 3, 2024

More on Cellular senescence

Latest

Related