AgingResearch.NewsJoin free

Nicotinamide + d-ribose

Intervention

1 paper6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Human trial1

Outcomes

6

Mental concentration

upin humans1

1 study

  1. Nicotinamide + d-ribose improves mental concentration in humans.

    “Subjects in the RiaGev group showed less fatigue, improved mental concentration and motivation over the baseline (p = 0.015, 0.018, and 0.012, respectively)”

    Human trialhealthy adults; compared with baseline1520 mg twice daily7 days

    A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD⁺ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

    Nutrients26 May 2022

Fatigue

downin humans1

1 study

  1. Nicotinamide + d-ribose decreases fatigue in humans.

    “Subjects in the RiaGev group showed less fatigue, improved mental concentration and motivation over the baseline (p = 0.015, 0.018, and 0.012, respectively)”

    Human trialhealthy adults; compared with baseline1520 mg twice daily7 days

    A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD⁺ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

    Nutrients26 May 2022

Waking salivary cortisol

downin humans1

1 study

  1. Nicotinamide + d-ribose decreases waking salivary cortisol in humans.

    “The waking salivary cortisol of the subjects steadily and significantly decreased (p = 0.026) in the RiaGev group in contrast to the placebo.”

    Human trialhealthy adults; compared with placebo1520 mg twice daily7 days

    A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD⁺ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

    Nutrients26 May 2022

More on Waking salivary cortisol

Insulin secretion

no changein humans1

1 study

  1. Nicotinamide + d-ribose has no effect on insulin secretion in humans.

    “without significant changes in insulin secretion (p = 0.796)”

    Human trialhealthy adults1520 mg twice daily7 days

    A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD⁺ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

    Nutrients26 May 2022

Blood glucose

downin humans1

1 study

  1. Nicotinamide + d-ribose decreases blood glucose in humans.

    “Seven-day supplementation with RiaGev significantly (p = 0.013) reduced overall blood glucose”

    Human trialhealthy adultsblood1520 mg twice daily7 days

    A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD⁺ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

    Nutrients26 May 2022

More on Blood glucose

NADP+

upin humans1

1 study

  1. Nicotinamide + d-ribose increases NADP+ in humans (+27% versus placebo; p = 0.033).

    “significantly increased the NAD+ metabolome in blood, especially NADP+ by 27% compared to the placebo group”

    Human trialhealthy adults; compared with placeboblood1520 mg twice daily7 days

    A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD⁺ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

    Nutrients26 May 2022

More on NADP+

Latest

Related