D-allulose

1. D-allulose decreases AGE-related autofluorescence in worms (∼22% suppression at 10 mM and ∼20% at 25 mM).

   “only d-allulose significantly suppressed autofluorescence (∼22% at 10 mM and ∼20% at 25 mM; corrected p < 0.01)”

   Model organisms10 and 25 mM

   An eight-ketohexose stereoisomer screen identifies d-allulose as a stereoselective suppressor of AGE-related autofluorescence in Caenorhabditis elegans

   Bioscience, biotechnology, and biochemistry·Oct 16, 2026

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1. D-allulose decreases insulin resistance in mice.

   “supplementation with allulose improves obesity-induced insulin resistance by mitigating the disruptions in macrophage and mitochondrial function.”

   Animalsobesity-induced

   D-Allulose Ameliorates Dysregulated Macrophage Function and Mitochondrial NADH Homeostasis, Mitigating Obesity-Induced Insulin Resistance

   Nutrients·Sep 29, 2023

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1. D-allulose improves mitochondrial translation in mice.

   “D-allulose supplementation improved mitochondrial NADH homeostasis and translation in both the liver and white adipose tissue of HFD-fed mice.”

   Animalsin HFD-fed mice

   D-Allulose Ameliorates Dysregulated Macrophage Function and Mitochondrial NADH Homeostasis, Mitigating Obesity-Induced Insulin Resistance

   Nutrients·Sep 29, 2023

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1. D-allulose decreases inflammation in mice.

   “D-allulose effectively suppressed IFN-γ, restored chemokine signaling, and enhanced macrophage function in the livers of HFD-fed mice.”

   Animalsin HFD-fed miceliver

   D-Allulose Ameliorates Dysregulated Macrophage Function and Mitochondrial NADH Homeostasis, Mitigating Obesity-Induced Insulin Resistance

   Nutrients·Sep 29, 2023

More on Inflammation