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[d-ala2]gip

Intervention

1 paper studies it2 findings

Across all fields, 1 paper: none in people yet, 1 in cells

More peptides

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Japan Association for Diabetes Education and Care and 2 more
  • Cells1

Outcomes

2

Oxidative stress and ROS signaling

downin human cells1

1 study

  1. [d-ala2]gip decreases oxidative stress and ROS signaling in human cells.

    “all of which were significantly blocked by [D-Ala2]GIP(1-42) or an inhibitor of NADPH oxidase activity.”

    Cellsin AGE-exposed human U937 macrophages

    Glucose-Dependent Insulinotropic Polypeptide Inhibits AGE-Induced NADPH Oxidase-Derived Oxidative Stress Generation and Foam Cell Formation in Macrophages Partly via AMPK Activation

    International journal of molecular sciences

More on Oxidative stress and ROS signaling

Oxidized low-density lipoprotein uptake

downin human cells1

1 study

  1. [d-ala2]gip decreases oxidized low-density lipoprotein uptake in human cells.

    “all of which were significantly blocked by [D-Ala2]GIP(1-42) or an inhibitor of NADPH oxidase activity.”

    Cellsin AGE-exposed human U937 macrophages

    Glucose-Dependent Insulinotropic Polypeptide Inhibits AGE-Induced NADPH Oxidase-Derived Oxidative Stress Generation and Foam Cell Formation in Macrophages Partly via AMPK Activation

    International journal of molecular sciences

More on Oxidized low-density lipoprotein uptake

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