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Cyclic loading

Cyclic loading has been studied in 2 papers since 2018: none in people yet, 1 in animals, 1 review. The research so far is in animals. The newest paper, Jun 28, 2020: “Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice”.

Exposure

2 papers study it1 findingUpdated

See all 2

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: European Cooperation in Science and Technology and 3 more
  • Animals1

What did studies of Cyclic loading find?

1

Studies of Cyclic loading measured 1 outcome; the most studied are load-induced bone adaptation (1 study).

Load-induced bone adaptation

upin mice1

1 study

  1. Cyclic loading induces load-induced bone adaptation in mice.

    “When subjected to 4 weeks of cyclic loading, young but not aged PolgA(D257A/D257A) caudal vertebrae showed load-induced bone adaptation”

    AnimalsHomozygous Polg D257A mutation; adaptation observed in young but not aged micecaudal vertebra4 weeks

    Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice

    Journal of cachexia, sarcopenia and muscle

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