CU06-1004

1. CU06-1004 improves cognitive function in mice.

   “improved motor and cognitive functions in aged mice that received long-term CU06-1004 administration.”

   Animals

   Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model

   Fluids and barriers of the CNS·Feb 1, 2023

1. CU06-1004 decreases neuronal injury in mice.

   “CU06-1004 supplementation also reduced the extravasation of plasma IgG by improving BBB integrity in the aged mouse brain, associated with reductions in neuronal injury.”

   Animals

   Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model

   Fluids and barriers of the CNS·Feb 1, 2023

1. CU06-1004 decreases cerebrovascular senescence in mice.

   “Long-term administration of CU06-1004 alleviated age-associated cerebral microvascular rarefaction and cerebrovascular senescence in the aged mouse brain.”

   Animals

   Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model

   Fluids and barriers of the CNS·Feb 1, 2023

1. CU06-1004 inhibits cellular senescence in human cells.

   “pretreatment of HBMECs with CU06-1004 considerably reduced oxidative stress-induced cytotoxicity, reactive oxygen species generation, senescence-associated β-galactosidase activity, senescence marker expression”

   CellsH2O2-treated

   Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model

   Fluids and barriers of the CNS·Feb 1, 2023

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