Compound C8

1 paper3 findings

1 lab in 1 country

Funders: National Key Research and Development Program of China and 1 more

Animals1

Outcomes

3

Age-related dysfunctions

downin mice1

1 study

Compound C8 decreases age-related dysfunctions in mice.
“In a naturally aging mouse model, compound C8 effectively alleviated age-related dysfunctions and markers.”
Animalsin a naturally aging mouse model
Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions
Journal of medicinal chemistry17 Feb 2024

Lifespan

upin worms1

1 study

Compound C8 extends lifespan in worms.
“Activator C8 showed potent activity in delaying aging in senescent HL-7702 cells and extended the lifespan of Caenorhabditis elegans.”
Model organisms
Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions
Journal of medicinal chemistry17 Feb 2024

NAD+

upin cells1

1 study

Compound C8 increases NAD+ in cells.
“compound C8 effectively activated NAMPT and promoted the biosynthesis of NAD+.”
Cellsin vitro
Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions
Journal of medicinal chemistry17 Feb 2024

Latest

Journal of Medicinal Chemistry17 Feb

Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions

Experiments in wormsInterventions