Compound 4b

1. Compound 4b decreases oxidative stress and ROS signalling in worms.

   “increasing GSH activity, reducing MDA content, and decreasing ROS accumulation.”

   Model organismsoxidative stress

   Design, Synthesis, and Evaluation of Nitroxide Radical Derivatives Based on Rhein as Potential Anti-Aging Agents Targeting the Keap1-Nrf2 Pathway

   Drug design, development and therapy·19 Jun 2025

More on Oxidative stress and ROS signalling

1. Compound 4b extends lifespan in worms.

   “In the C. elegans model, 4b extended the average lifespan and enhanced stress resistance”

   Model organisms

   Design, Synthesis, and Evaluation of Nitroxide Radical Derivatives Based on Rhein as Potential Anti-Aging Agents Targeting the Keap1-Nrf2 Pathway

   Drug design, development and therapy·19 Jun 2025