Complete revascularization

Complete revascularization has been studied in 3 papers since 2025: 1 trial and 1 observational study in people, 1 review; 2 in the past year. The newest paper, Oct 31, 2026: “Secondary Cardiovascular Prevention After Coronary Heart Disease in a North African country: Findings From the NATURE STOP-CHD Tunisian National Registry”.

Intervention

3 papers study it3 findingsUpdated

1 new paper in 30 daysSee all 3 papers on complete revascularization

At a glance

The findings reach people, from one lab or study. 2 independent labs in 2 countries.

“Complete revascularization reduced the primary endpoint with no significant interaction between revascularization strategy and CFS category (p for interaction = 0.769).”
Consistent benefit of physiology-guided complete revascularization across the spectrum of frailty in older patients with myocardial infarction: a prespecified analysis of the FIRE trialAge and ageing2026doi:10.1093/ageing/afag078

1 of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.
  • 2 independent labs in 2 countries
  • 1 finding against
  • Funders: Sahajanand Medical Technologies and 1 more
  • Human trial1
  • Humans1

Studies in people

1 study gave complete revascularization to people and measured what changed.

What changedDesignPeopleSource

down: Decreases death, MI, stroke, or ischemia-driven revascularization

Randomized trial3 years1,010 people≥75 yearsOlder adults; older patients with MI and multivessel diseaseAge and ageing, Mar 16, 2026

What did studies of complete revascularization find?

2

Studies of complete revascularization measured 2 outcomes; the most studied are mortality (1 study) and death, MI, stroke, or ischemia-driven revascularization (1).

Mortality

no changein humans1downin humans1OR 1.03–1.75

1 study
  1. Complete revascularization showed no clear effect on mortality in humans (elderly patients with multivessel CAD presenting with STEMI) (OR 1.03, 95% CI 0.61-1.72; p = 0.92).

    “there was no significant difference in risk of all-cause mortality with complete versus culprit-only revascularization in studies of only STEMI patients”

    Reviewelderly patients with multivessel CAD presenting with STEMIn = 11,994

    Association of complete revascularization with safety and outcomes in elderly patients with multi-vessel coronary artery disease: a systematic review and meta-analysis

    International journal of cardiology. Heart & vasculature

  2. Complete revascularization decreases mortality in humans (elderly patients with multivessel CAD) (OR 1.75, 95% CI 1.40-2.18; p < 0.001).

    “Patients who underwent complete revascularization had significantly lower all-cause and CV mortality compared to culprit-only revascularization”

    Reviewelderly patients with multivessel CAD29.0 monthsn = 11,994

    Association of complete revascularization with safety and outcomes in elderly patients with multi-vessel coronary artery disease: a systematic review and meta-analysis

    International journal of cardiology. Heart & vasculature

Death, MI, stroke, or ischemia-driven revascularization

downin humans1

1 study
  1. Complete revascularization decreases death, MI, stroke, or ischemia-driven revascularization in humans (older patients with MI and multivessel disease).

    “Complete revascularization reduced the primary endpoint with no significant interaction between revascularization strategy and CFS category (p for interaction = 0.769).”

    Human trialolder patients with MI and multivessel diseasen = 1,010

    Consistent benefit of physiology-guided complete revascularization across the spectrum of frailty in older patients with myocardial infarction: a prespecified analysis of the FIRE trial

    Age and ageing

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 02 papers in 12 months