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Fish oil + cocoa flavanols

Fish oil + cocoa flavanols has been studied in 1 paper since 2023: 1 trial in people. The newest paper, Jun 12, 2023: “A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study”.

Intervention

1 paper studies it8 findingsUpdated

See all 1 papers on fish oil + cocoa flavanols

At a glance

The findings reach people, from one lab or study. 1 lab in 1 country.

“No significant impact of intervention on picture recognition performance was evident”
A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design studyThe American journal of clinical nutrition2023doi:10.1016/j.ajcnut.2023.06.008

1 of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: Abbott Nutrition and 5 more
  • Human trial1

Studies in people

1 study gave fish oil + cocoa flavanols to people and measured what changed.

What changedDesignPeopleSource

no change: Has no effect on cognitive function

down: Impairs cognitive function

down: Decreases brain

Randomized trial12-mo258 people57% were femalesaged ≥55 yAdults aged ≥55 y with subjective cognitive impairment or mild cognitive impairmentThe American journal of clinical nutrition, Jun 12, 2023

What did studies of fish oil + cocoa flavanols find?

4

Studies of fish oil + cocoa flavanols measured 4 outcomes, among them cognitive function, triglyceride and brain.

Cognitive function

downin humans1no changein humans1

1 study

  1. Fish oil + cocoa flavanols impair cognitive function in humans.

    “There was no significant effect of the intervention on any of the secondary composite or individual cognitive outcomes, with the exception of reaction time variability (P = 0.007), executive function (P < 0.001), and alertness (P < 0.001).”

    Human trial12-mon = 258

    A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

    The American journal of clinical nutrition

  2. Fish oil + cocoa flavanols showed no clear effect on cognitive function in humans.

    “No significant impact of intervention on picture recognition performance was evident”

    Human trial12-mon = 258

    A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

    The American journal of clinical nutrition

  3. Fish oil + cocoa flavanols impair cognitive function in humans (subjective cognitive impairment or mild cognitive impairment) (118.6 [SD 25.3] at baseline versus 113.3 [SD 25.4] at 12 mo, P < 0.001).

    “with a decline in function observed in the OM3FLAV group (118.6 [SD 25.3] at baseline versus 113.3 [SD 25.4] at 12 mo for executive function) relative to the control”

    Human trialsubjective cognitive impairment or mild cognitive impairmentDHA-rich fish oil and flavanol-rich dark chocolate12 mon = 197

    A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

    The American journal of clinical nutrition

Triglyceride

downin humans1

1 study

  1. Fish oil + cocoa flavanols decrease triglyceride in humans (-22% vs no change).

    “The intervention decreased plasma triglyceride levels by 22% in the OM3FLAV group by 3 mo, with no change in the control group (P < 0.001, ).”

    Human trial12-mon = 258

    A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

    The American journal of clinical nutrition

  2. Fish oil + cocoa flavanols decrease triglyceride in humans (subjective cognitive impairment or mild cognitive impairment) (P < 0.001).

    “Compared with the control group, OM3FLAV increased plasma HDL, total cholesterol ratio (P < 0.001), and glucose (P = 0.008) and reduced TG concentrations (P < 0.001) by 3 mo”

    Human trialsubjective cognitive impairment or mild cognitive impairmentDHA-rich fish oil and flavanol-rich dark chocolateplasma3 to 12 mon = 197

    A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

    The American journal of clinical nutrition

More on Triglyceride

Brain

downin humans1

1 study

  1. Fish oil + cocoa flavanols decrease brain in humans.

    “For cortical volume (mm3), a group×time effect was evident (P = 0.039), with a greater decrease in the OM3FLAV (446,813 [2850] at baseline, 441,087 [2850] at 12 mo) compared with the control (453,634 [3239] at baseline, 450,829 [3239] at 12 mo).”

    Human trialcortical volume12-mon = 140

    A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

    The American journal of clinical nutrition

  2. Fish oil + cocoa flavanols decrease brain in humans (subjective cognitive impairment or mild cognitive impairment) (P = 0.039).

    “and an associated decrease in cortical volume (P = 0.039).”

    Human trialsubjective cognitive impairment or mild cognitive impairmentDHA-rich fish oil and flavanol-rich dark chocolatebrain12 mon = 110

    A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

    The American journal of clinical nutrition

BDNF

no changein humans1

1 study

  1. Fish oil + cocoa flavanols showed no clear effect on BDNF in humans.

    “No impact of intervention was observed for BDNF concentrations (P = 0.265).”

    Human trial12-mon = 258

    A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

    The American journal of clinical nutrition

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