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Cng channel blocker

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: China Postdoctoral Science Foundation and 1 more
  • Model organisms1

Outcomes

2

Lifespan

upin worms1

1 study

  1. Cng channel blocker extends lifespan in worms.

    “Administering a CNG channel blocker to worm larvae activates intestinal UPRER and increases adult longevity.”

    Model organisms

    Inhibition of a cyclic nucleotide-gated channel on neuronal cilia activates unfolded protein response in intestinal cells to promote longevity

    Proceedings of the National Academy of Sciences of the United States of America10 Jun 2024

ER unfolded protein response

upin worms1

1 study

  1. Cng channel blocker activates ER unfolded protein response in worms.

    “Administering a CNG channel blocker to worm larvae activates intestinal UPRER and increases adult longevity.”

    Model organismsintestinal cell

    Inhibition of a cyclic nucleotide-gated channel on neuronal cilia activates unfolded protein response in intestinal cells to promote longevity

    Proceedings of the National Academy of Sciences of the United States of America10 Jun 2024

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