AgingResearch.NewsJoin free

tax-4

Gene

2 papers2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: China Postdoctoral Science Foundation and 1 more
  • Model organisms2

Effects

2

ER unfolded protein response

downin worms1

1 study

  1. tax-4 inhibits ER unfolded protein response in worms.

    “Conversely, constitutive activation of TAX-4 attenuates intestinal UPRER in ciliary mutants.”

    Model organismsconstitutive TAX-4 activation in ciliary mutantsintestinal cell

    Inhibition of a cyclic nucleotide-gated channel on neuronal cilia activates unfolded protein response in intestinal cells to promote longevity

    Proceedings of the National Academy of Sciences of the United States of America10 Jun 2024

More on ER unfolded protein response

Lifespan

downin worms1

1 study

  1. tax-4 shortens lifespan in worms.

    “Notably, deactivating the cyclic nucleotide-gated (CNG) channel TAX-4 on the ciliary membrane promotes lifespan extension through a UPRER-dependent mechanism.”

    Model organismsshown by TAX-4 deactivation; lifespan extension depends on UPRER

    Inhibition of a cyclic nucleotide-gated channel on neuronal cilia activates unfolded protein response in intestinal cells to promote longevity

    Proceedings of the National Academy of Sciences of the United States of America10 Jun 2024

Latest

Related