Clearance of P21-HIGHLY-EXPRESSING cells

1. Clearance of P21-HIGHLY-EXPRESSING cells decrease inflammation in mice.

   “Clearance of p21high cells reduces inflammation and alleviates age-related transcriptomic signatures of various tissues.”

   Animals

   Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

   Cell metabolism·6 Aug 2024

More on Inflammation

1. Clearance of P21-HIGHLY-EXPRESSING cells improve physical function in mice.

   “clearance of p21high cells improves physical function at all remaining stages of life, suggesting healthspan extension.”

   Animals

   Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

   Cell metabolism·6 Aug 2024

1. Clearance of P21-HIGHLY-EXPRESSING cells extend lifespan in mice.

   “monthly clearance, starting from 20 months, of a small number of cells that highly express p21Cip1 (p21high) improves cardiac and metabolic function and extends both median and maximum lifespans in mice.”

   Animals

   Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

   Cell metabolism·6 Aug 2024