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Folic acid + cobalamin + cholecalciferol + eicosapentaenoic acid + docosahexaenoic acid

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Human trial1

Outcomes

2

Omega-3 index

upin humans1

1 study

  1. Folic acid + cobalamin + cholecalciferol + eicosapentaenoic acid + docosahexaenoic acid increases omega-3 index in humans (all P < .001).

    “A significant increase in the nutrient status biomarkers Omega-3 Index, serum 25-hydroxycholecalciferol, red blood cell folate, and holotranscobalamin was observed in the intervention group”

    Human trial12 weeksn = 112

    Multimicronutrient and omega-3 fatty acid supplementation reduces low-grade inflammation in older participants: An exploratory study

    Nutrition research (New York, N.Y.)19 Jun 2025

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INFLA-score

downin humans1

1 study

  1. Folic acid + cobalamin + cholecalciferol + eicosapentaenoic acid + docosahexaenoic acid decreases INFLA-score in humans (P = .036).

    “the intervention significantly decreased the INFLA score compared to placebo (P = .036)”

    Human trial12 weeksn = 112

    Multimicronutrient and omega-3 fatty acid supplementation reduces low-grade inflammation in older participants: An exploratory study

    Nutrition research (New York, N.Y.)19 Jun 2025

More on INFLA-score

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