Childhood friendships

Exposure

4 papers study it6 findings

  • 3 independent labs in 2 countries
  • Funders: Government of Jiangsu Province and 3 more
  • Humans4

Outcomes

1

Cognitive decline

downin humans1

1 study
  1. Childhood friendships decrease cognitive decline in humans (β = 0.19, 95% CI: 0.10 to 0.28).

    “comparing to participants with poor childhood friendships, those with better childhood friendships had lower rates of cognitive decline”

    Humansgood childhood friendships vs poorn = 4,350

    Association between childhood friendship and cognitive ageing trajectory in later life: evidence from the China Health and Retirement Longitudinal Study (CHARLS)

    BMC geriatricsJun 9, 2022

Associations

5

Social isolation

downin humans1

1 study
  1. Childhood friendships are associated with social isolation in humans.

    “Childhood friendships were negatively associated with frailty and social isolation”

    Humans

    The role of social isolation in the association between childhood friendships and frailty in older adults: evidence from a national cohort study

    BMC geriatricsMar 11, 2026

Frailty

downin humans1

1 study
  1. Childhood friendships are associated with frailty in humans.

    “Childhood friendships were negatively associated with frailty”

    Humans

    The role of social isolation in the association between childhood friendships and frailty in older adults: evidence from a national cohort study

    BMC geriatricsMar 11, 2026

Grip strength

downin humans1OR 1.21

1 study
  1. Childhood friendships are associated with grip strength in humans (OR = 1.21; 95 % CI = 1.09-1.34).

    “and low grip strength (OR = 1.21; 95 % CI = 1.09-1.34)”

    Humansafter controlling for covariatesn = 12,170

    The mediating effect of depressive symptoms on the association between childhood friendship and physical function in middle-aged and older adults: Evidence from the China Health and Retirement Longitudinal Study (CHARLS)

    Journal of affective disordersMay 20, 2024

Instrumental activities of daily living disability

upin humans1OR 1.25

1 study
  1. Childhood friendships are associated with instrumental activities of daily living disability in humans (OR = 1.25; 95 % CI = 1.12-1.40).

    “IADL disability (OR = 1.25; 95 % CI = 1.12-1.40)”

    Humansafter controlling for covariatesn = 12,170

    The mediating effect of depressive symptoms on the association between childhood friendship and physical function in middle-aged and older adults: Evidence from the China Health and Retirement Longitudinal Study (CHARLS)

    Journal of affective disordersMay 20, 2024

Basic activities of daily living disability

upin humans1OR 1.18

1 study
  1. Childhood friendships are associated with basic activities of daily living disability in humans (OR = 1.18; 95 % CI = 1.05-1.32).

    “low-quality CF was associated with an increased prevalence of BADL disability (OR = 1.18; 95 % CI = 1.05-1.32)”

    Humansafter controlling for covariatesn = 12,170

    The mediating effect of depressive symptoms on the association between childhood friendship and physical function in middle-aged and older adults: Evidence from the China Health and Retirement Longitudinal Study (CHARLS)

    Journal of affective disordersMay 20, 2024

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months