Cell-free fat extract

1. Cell-free fat extract inhibits oxidative stress and ROS signalling in mouse cells.

   “In vitro studies demonstrated that CEFFE pre-treatment alleviated the phenotype of Control mice by inhibiting oxidative stress, promoting proliferation, and enhancing hormone secretion.”

   Cellsin vitrogranulosa cell

   Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescence

   Stem cell research & therapy·30 May 2025

More on Oxidative stress and ROS signalling

1. Cell-free fat extract inhibits cellular senescence in mice.

   “Early prophylactic administration of CEFFE in adult mice can prevent DOR and extend their reproductive lifespan by inhibiting granulosa cell senescence.”

   Animalsin primary mouse granulosa cellsgranulosa cell

   Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescence

   Stem cell research & therapy·30 May 2025

More on Cellular senescence

1. Cell-free fat extract increases pregnancy rate in mice.

   “CEFFE treatment enhanced embryo quality and development, induced a higher pregnancy rate, reduced the number of abnormal pregnancies, and increased the litter size and the number of live births.”

   Animalsin aging micetail vein injections200 μL per mouse every 3 daysthree monthsfemales

   Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescence

   Stem cell research & therapy·30 May 2025

1. Cell-free fat extract decreases follicular atresia in mice.

   “CEFFE treatment effectively preserved ovarian function in aging mice, improving ovarian weight, hormone levels, and follicular development, and reduced follicular atresia.”

   Animalsin aging micetail vein injections200 μL per mouse every 3 daysthree monthsfemales

   Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescence

   Stem cell research & therapy·30 May 2025