Ceftriaxone
Ceftriaxone has been studied in 5 papers since 2017: 1 trial and 1 observational study in people, 2 in animals; 2 in the past year.
See all 7 papers on ceftriaxone
At a glance
The findings reach people, from one lab or study. 3 independent labs in 3 countries; 20 trials, none about aging, 6 with no results posted.
“perioperative use of ceftriaxone, a long-acting β-lactam antibiotic, can prevent the development of PND in elderly surgical patients.”
None of its findings points the other way.
- 3 independent labs in 3 countries
- 20 trials, none about aging, 6 with no results posted
- Funders: National Science and Technology Council and 2 more
- Human trial1
- Humans1
- Animals1
Studies in people
1 study gave ceftriaxone to people and measured what changed.
| What changed | Design | People | Source |
|---|---|---|---|
| Trial | older than 60 yearsOlder adults; elderly surgical patients | Molecular psychiatry, Jul 14, 2025 |
What did studies of ceftriaxone find?
5Studies of ceftriaxone measured 5 outcomes; the most studied are perioperative neurocognitive disorder (1 study), TH (1) and pyramidal neuron density (1).
Perioperative neurocognitive disorder
downin humans1
1 study
Perioperative neurocognitive disorder
downin humans1
Ceftriaxone prevents perioperative neurocognitive disorder in humans (elderly surgical patients).
“perioperative use of ceftriaxone, a long-acting β-lactam antibiotic, can prevent the development of PND in elderly surgical patients.”
Human trialelderly surgical patients
Molecular psychiatry
TH
upin rats1
1 study
TH
upin rats1
Ceftriaxone increases TH in OXYS rats.
“CEF treatment at a dose of 50mg/kg significantly augmented this parameter.”
Animalsin OXYS ratsstriatum50 mg/kg/day36 days
Behavioural brain research
Pyramidal neuron density
upin rats1
1 study
Pyramidal neuron density
upin rats1
Ceftriaxone increases pyramidal neuron density in OXYS rats.
“Both doses of CEF increased the density of pyramidal neurons in the CA1 area in OXYS rats.”
Animalsin OXYS ratshippocampal CA1 area50 or 100 mg/kg/day36 days
Behavioural brain research
Novel object recognition
upin rats1
1 study
Novel object recognition
upin rats1
Ceftriaxone improves novel object recognition in OXYS rats.
“restored the deficit in the novel object recognition in OXYS rats”
Animalsin OXYS rats100 mg/kg/day36 days
Behavioural brain research
Impairments of movement
downin rats1
1 study
Impairments of movement
downin rats1
Ceftriaxone decreases impairments of movement in OXYS rats.
“Chronic CEF administration in a dose of 100mg/kg partially inhibited impairments of movement”
Animalsin OXYS rats100 mg/kg/day36 days
Behavioural brain research
What is ceftriaxone linked with?
1Studies link ceftriaxone with 1 measure, most often mortality (1 study).
Mortality
upin humans1
1 study
Mortality
upin humans1
Ceftriaxone is associated with mortality in humans (older nursing home residents with suspected COVID-19) (p 0.004).
“According to multivariate logistic regression age (p 0.010), Barthel index <60 (p 0.002), presence of tachypnea (p 0.021), fever (p 0.006) and the use of ceftriaxone (p 0.004) were associated with mortality.”
Humansolder nursing home residents with suspected COVID-19n = 419
BMC geriatrics
Who is developing ceftriaxone?
1 company: GlaxoSmithKline.
- Companies
- GlaxoSmithKlinePhase 3gonorrhea
Trial sponsors
Company2 trialsPhase 4940 people
Company2 trialsPhase 4257 people
Company2 trialsPhase 3424 people
Company2 trialsPhase 3361 people
Company1 trialPhase 3628 people
Company1 trialPhase 3599 people
Company1 trialPhase 371 people
Company1 trialPhase 214 people