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CD4 t cells

Intervention

1 paper studies it3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: European Research Council and 5 more
  • Animals1

Outcomes

3

Healthspan

upin mice1

1 study

  1. CD4 t cells improve healthspan in mice.

    “ultimately enhancing the health span in this mouse model”

    Animalsin Tfamfl/flCd4Cre mice

    CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

    Science immunology

Cellular senescence

downin mice1

1 study

  1. CD4 t cells decrease cellular senescence in mice.

    “mitigated premature inflammaging and senescence, ultimately enhancing the health span in this mouse model”

    Animalsin Tfamfl/flCd4Cre mice

    CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

    Science immunology

More on Cellular senescence

Gut barrier dysfunction

downin mice1

1 study

  1. CD4 t cells prevent gut barrier dysfunction in mice.

    “Microbiota depletion or adoptive transfer of total CD4 T cells or a Treg cell-enriched pool prevented gut barrier dysfunction”

    Animalsin Tfamfl/flCd4Cre mice

    CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

    Science immunology

Funding

7 grants since 2017

National Institute of Allergy and Infectious DiseasesUS$3.8mUKRI | Medical Research Council£3.1mNational Heart, Lung, and Blood InstituteUS$1.3m

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