CASP4 antisense oligonucleotide

CASP4 antisense oligonucleotide decreases neurotoxicity in mice.

“Inhibition of CASP4 by its antisense oligonucleotide ameliorated TDP-43 pathology and subsequent neurotoxicity in CASP4 mice.”

AnimalsHuman CASP4 transgenic mice

Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology

Nature communications·27 May 2026

CASP4 antisense oligonucleotide decreases TDP-43 pathology in mice.

“Inhibition of CASP4 by its antisense oligonucleotide ameliorated TDP-43 pathology and subsequent neurotoxicity in CASP4 mice.”

AnimalsHuman CASP4 transgenic mice

Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology

Nature communications·27 May 2026