AgingResearch.NewsJoin free

Cardiac resynchronization therapy defibrillator

Cardiac resynchronization therapy defibrillator has been studied in 7 papers since 2016: 7 observational studies in people. The newest paper, Oct 14, 2024: “Predictors of death without prior appropriate therapy in ICD recipients: the comorbidities, frailty and functional status (COMFFORT study)”.

Exposure

7 papers study it3 findingsUpdated

See all 7 papers on cardiac resynchronization therapy defibrillator

At a glance

The findings reach people, from one lab or study. 2 independent labs in 2 countries.

“There were no significant differences in mortality between patients with CRT-D versus CRT-P (P = 0.3386).”
When Is Cardiac Resynchronization Therapy with a Defibrillator Indicated in Patients with Heart Failure, Especially Elderly Patients?International heart journal2023doi:10.1536/ihj.22-418

1 of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • 1 finding against
  • Funders: Abbott and 3 more
  • 2 of 3 findings with company ties
  • Humans7

What did studies of cardiac resynchronization therapy defibrillator find?

1

Studies of cardiac resynchronization therapy defibrillator measured 1 outcome; the most studied are mortality (2 studies).

Mortality

no changein humans1downin humans1HR 0.9

2 studies

  1. Cardiac resynchronization therapy defibrillator was not clearly linked with mortality in patients undergoing CRT (P = 0.3386).

    “There were no significant differences in mortality between patients with CRT-D versus CRT-P (P = 0.3386).”

    Humansin patients undergoing CRTn = 285

    When Is Cardiac Resynchronization Therapy with a Defibrillator Indicated in Patients with Heart Failure, Especially Elderly Patients?

    International heart journal

  2. Cardiac resynchronization therapy defibrillator is linked with lower mortality in humans (heart failure with reduced ejection fraction, compared with ICD alone) (HR 0.90, 95% CI 0.86-0.95).

    “In the 2 oldest age strata, the hazard of death was lower in the CRT-D group (HR: 0.90; 95% CI: 0.86-0.95 and HR: 0.81; 95% CI: 0.72-0.90, respectively; P < 0.001)”

    Humansheart failure with reduced ejection fraction, compared with ICD alone

    Complications and Mortality Following CRT-D Versus ICD Implants in Older Medicare Beneficiaries With Heart Failure

    JACC. Heart failure

What is cardiac resynchronization therapy defibrillator linked with?

1

Studies link cardiac resynchronization therapy defibrillator with 1 measure, most often heart failure hospitalization (1 study).

Heart failure hospitalization

downin humans1HR 0.82

1 study

  1. Cardiac resynchronization therapy defibrillator is linked with a lower risk of heart failure hospitalization in humans (heart failure with reduced ejection fraction, compared with ICD alone) (HR 0.82, 95% CI 0.74-0.92).

    “the hazard of heart failure hospitalization was lower for CRT-D vs ICD in the 85+ years age group (HR: 0.82; 95% CI: 0.74-0.92; P < 0.001).”

    Humansheart failure with reduced ejection fraction, compared with ICD alone

    Complications and Mortality Following CRT-D Versus ICD Implants in Older Medicare Beneficiaries With Heart Failure

    JACC. Heart failure

Latest

Related