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Caloric restriction + voluntary wheel running

Caloric restriction + voluntary wheel running has been studied in 2 papers since 2016: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Jun 26, 2025: “Muscle Type-Specific Modulation of Autophagy Signaling in Obesity: Effects of Caloric Restriction and Exercise”.

Intervention

2 papers study it2 findingsUpdated

See all 2

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Hanyang University and 6 more
  • Animals2

What did studies of Caloric restriction + voluntary wheel running find?

2

Studies of Caloric restriction + voluntary wheel running measured 2 outcomes; the most studied are total mass (1 study) and dystrophin glycoprotein complex disruption (1).

Total mass

downin mice1

1 study

  1. Caloric restriction + voluntary wheel running decreases total mass in mice.

    “Notably, CR+Ex reduced total mass, lean mass, and fat mass in obese mice.”

    Animalsin obese mice

    Muscle Type-Specific Modulation of Autophagy Signaling in Obesity: Effects of Caloric Restriction and Exercise

    Journal of obesity & metabolic syndrome

Dystrophin glycoprotein complex disruption

downin rats1

1 study

  1. Caloric restriction + voluntary wheel running protects against dystrophin glycoprotein complex disruption in rats.

    “In contrast, OCR and OCRWR provided significant protection against age-related DGC disruption.”

    Animalsage-related changesplantaris muscle8% caloric restrictionlifelong

    Age-related alterations in the sarcolemmal environment are attenuated by lifelong caloric restriction and voluntary exercise

    Experimental gerontology

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