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Clostridium butyricum + bifidobacterium infantis

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Chinese Academy of Medical Sciences and 1 more
  • Animals1

Outcomes

2

OCLN

upin mice1

1 study

  1. Clostridium butyricum + bifidobacterium infantis increases OCLN in mice.

    “CB increased E-cadherin and occludin expressions.”

    AnimalsDSS-induced acute colitisgavagecolonic mucosamales

    Probiotics reduce the severity of DSS-induced colitis in aged mice by enhancing intestinal barrier function and modulating gut microbiota

    GeroScience13 Oct 2025

More on OCLN

CDH1

upin mice1

1 study

  1. Clostridium butyricum + bifidobacterium infantis increases CDH1 in mice.

    “CB increased E-cadherin and occludin expressions.”

    AnimalsDSS-induced acute colitisgavagecolonic mucosamales

    Probiotics reduce the severity of DSS-induced colitis in aged mice by enhancing intestinal barrier function and modulating gut microbiota

    GeroScience13 Oct 2025

More on CDH1

Associations

1

Colitis

downin mice1

1 study

  1. Clostridium butyricum + bifidobacterium infantis lowers the risk of colitis in mice.

    “CB and VSL#3 alleviated colitis, evidenced by significantly lower DAI and histopathologic scores and increased colon lengths.”

    AnimalsDSS-induced acute colitisgavagecolonmales

    Probiotics reduce the severity of DSS-induced colitis in aged mice by enhancing intestinal barrier function and modulating gut microbiota

    GeroScience13 Oct 2025

More on Colitis

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