MCL-1 inhibitors + BH3 mimetics
1 paper studies it1 finding
Across all fields, 1 paper: none in people yet, 1 in cells
- 1 lab in 1 country
- Funders: Advanced Scientific Computing Research and 4 more
- Cells1
Outcomes
1Senescent cell elimination
upin human cells1
1 study
Senescent cell elimination
upin human cells1
MCL-1 inhibitors + BH3 mimetics increase senescent cell elimination in human cells.
“we found synergy in combining MCL-1 selective inhibitors with other BH3 mimetics.”
Cellsin human non-transformed senescent cells (RPE-1, BJ, MRC-5)
Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells
Aging
Latest
Aging
Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells
Experiments in human cellsInterventions