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Bexarotene

Intervention

1 paper3 findings

PubChem 82146ChEBI 50859MeSH D000077610

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Agencia Estatal de Investigación and 5 more
  • Animals1

Outcomes

2

Sensorimotor and cognitive recovery

upin mice1

1 study

  1. Bexarotene improves sensorimotor and cognitive recovery in mice.

    “we established that BEX improved sensorimotor and cognitive recovery after MCAo in a myeloid-RXRα-specific and myeloid-RXRα-dependent manner.”

    Animalsafter MCAo; myeloid-RXRα-dependentbrainmale and females

    Retinoid-X-Receptor as a Mediator of Poststroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Hematogenous Macrophages

    The Journal of neuroscience : the official journal of the Society for Neuroscience14 Aug 2025

phagocytosis

upin mice1

1 study

  1. Bexarotene increases phagocytosis in mice.

    “With the in vivo phagocytosis model, we showed that BEX enhanced the phagocytic ability of aged MΦ.”

    Animalsin vivo phagocytosis modelmicroglia and hematogenous macrophages

    Retinoid-X-Receptor as a Mediator of Poststroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Hematogenous Macrophages

    The Journal of neuroscience : the official journal of the Society for Neuroscience14 Aug 2025

Associations

1

Microglial aging gene signature

mixedin mice1

1 study

  1. Bexarotene is associated with microglial aging gene signature in mice.

    “Meanwhile, the treatment with RXR agonist bexarotene (BEX) reversed the signature genes of microglia aging in the aged MΦ.”

    Animalsmicroglia and hematogenous macrophages

    Retinoid-X-Receptor as a Mediator of Poststroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Hematogenous Macrophages

    The Journal of neuroscience : the official journal of the Society for Neuroscience14 Aug 2025

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