1 paper studies it6 more mention it1 finding
Bexarotene
downin humans1
Bexarotene decreases MRI brain age in humans (-1.98 years, 95% CI [-3.75, -0.21 years] versus placebo, P = 0.034).
“treatment with bexarotene, along with promoting remyelination, was associated with significant decrease in MRI brain age [-1.98 years, 95% confidence interval (CI) [-3.75, -0.21 years] versus placebo over 6 months, P = 0.034]”
Human trialradiologically stable multiple sclerosis6 monthsn = 44
Exploratory analysis of biological age measures in a remyelination clinical trial
Brain communications
The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.