BC02-ADJUVANTED vzv ge subunit vaccine

1. BC02-ADJUVANTED vzv ge subunit vaccine increases memory T/B cell ratio in mice.

   “the ratio of memory T/B cells was markedly higher than in the control group”

   Animalscompared to control

   BC02-adjuvanted varicella-zoster virus glycoprotein E subunit vaccine overcomes immunosenescence to induce robust neutralizing antibodies and multifunctional T-cell immunity in seropositive aged murine models

   Human vaccines & immunotherapeutics·23 Jan 2026

More on Memory T/B cell ratio

1. BC02-ADJUVANTED vzv ge subunit vaccine increases neutralizing antibody titer in mice (1:122).

   “The neutralizing antibody titer reached 1:122, comparable to that of the commercial vaccine Shingrix®”

   Animals

   BC02-adjuvanted varicella-zoster virus glycoprotein E subunit vaccine overcomes immunosenescence to induce robust neutralizing antibodies and multifunctional T-cell immunity in seropositive aged murine models

   Human vaccines & immunotherapeutics·23 Jan 2026

More on Neutralizing antibody titer

1. BC02-ADJUVANTED vzv ge subunit vaccine increases IL-2-secreting CD4+ T cells in mice (5.7-fold).

   “gE-specific IFN-γ- and IL-2-secreting cells induced by the BC02-adjuvanted vaccine (gE+BC02-1) increased 11.8- and 5.7-fold compared to the single-adjuvant group”

   Animalscompared to single-adjuvant group

   BC02-adjuvanted varicella-zoster virus glycoprotein E subunit vaccine overcomes immunosenescence to induce robust neutralizing antibodies and multifunctional T-cell immunity in seropositive aged murine models

   Human vaccines & immunotherapeutics·23 Jan 2026

More on IL-2-secreting CD4+ T cells

1. BC02-ADJUVANTED vzv ge subunit vaccine increases IFN-γ-secreting CD4+ T cells in mice (11.8-fold).

   “gE-specific IFN-γ- and IL-2-secreting cells induced by the BC02-adjuvanted vaccine (gE+BC02-1) increased 11.8- and 5.7-fold compared to the single-adjuvant group”

   Animalscompared to single-adjuvant group

   BC02-adjuvanted varicella-zoster virus glycoprotein E subunit vaccine overcomes immunosenescence to induce robust neutralizing antibodies and multifunctional T-cell immunity in seropositive aged murine models

   Human vaccines & immunotherapeutics·23 Jan 2026

More on IFN-γ-secreting CD4+ T cells