IL-2-secreting CD4+ T cells

1. BC02-ADJUVANTED vzv ge subunit vaccine increases IL-2-secreting CD4+ T cells in mice (5.7-fold).

   “gE-specific IFN-γ- and IL-2-secreting cells induced by the BC02-adjuvanted vaccine (gE+BC02-1) increased 11.8- and 5.7-fold compared to the single-adjuvant group”

   Animalscompared to single-adjuvant group

   BC02-adjuvanted varicella-zoster virus glycoprotein E subunit vaccine overcomes immunosenescence to induce robust neutralizing antibodies and multifunctional T-cell immunity in seropositive aged murine models

   Human vaccines & immunotherapeutics·23 Jan 2026

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