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Attempt to discontinue therapy

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country

Outcomes

1

C-terminal telopeptide of type I collagen

upin humans1

1 study

  1. Attempt to discontinue therapy increases C-terminal telopeptide of type I collagen in humans (from 134 pg/mL to 575 pg/mL).

    “Additionally, her CTX (ref. range 104-1,008 pg/mL) levels rose from 134 pg/mL to 575 pg/mL, indicating increase bone turnover.”

    Human trialattempt to discontinue HRTfemales

    SAT-783 83y Old Woman On Long-Term Hormone Replacement Therapy (HRT) for Osteoporosis (OP) Management: n of 1, Revisiting the Role of HRT in OP Management

    ENDO 2025 abstract22 Oct 2025

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