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Atr inhibitors

Atr inhibitors has been studied in 1 paper since 2024: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Sep 17, 2024: “In vivo DNA replication dynamics unveil aging-dependent replication stress”.

Intervention

1 paper studies it6 findingsUpdated

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: H2020 European Research Council and 4 more
  • 3 of 6 findings with company ties
  • Animals1

What did studies of Atr inhibitors find?

6

Studies of Atr inhibitors measured 6 outcomes; the most studied are cell cycle regulation (1 study), inflammation (1) and replication origin firing efficiency (1).

Cell cycle regulation

no changein mice1

1 study

  1. Atr inhibitors have no effect on cell cycle regulation in mice.

    “without significantly enhancing the fraction of hepatocytes entering the cell cycle.”

    Animalsliver

    In vivo DNA replication dynamics unveil aging-dependent replication stress

    Cell

More on Cell cycle regulation

Inflammation

upin mice1

1 study

  1. Atr inhibitors induce inflammation in mice.

    “Inhibitors of the ATR checkpoint kinase fully restored origin firing efficiency in the old mice but at the expense of an inflammatory response”

    Animalsliver

    In vivo DNA replication dynamics unveil aging-dependent replication stress

    Cell

More on Inflammation

Replication origin firing efficiency

upin mice1

1 study

  1. Atr inhibitors increase replication origin firing efficiency in mice.

    “Inhibitors of the ATR checkpoint kinase fully restored origin firing efficiency in the old mice but at the expense of an inflammatory response”

    Animalsliver

    In vivo DNA replication dynamics unveil aging-dependent replication stress

    Cell

Killing of MN-bearing cancer cells by natural killer cells

downin human cells1

1 study

  1. Atr inhibitors decrease killing of MN-bearing cancer cells by natural killer cells in human cells.

    “Furthermore, ATRi reduces cGAS-mediated senescence and killing of MN-bearing cancer cells by natural killer cells.”

    Cells

    ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei

    Molecular cell

Cellular senescence

downin human cells1

1 study

  1. Atr inhibitors decrease cellular senescence in human cells.

    “Furthermore, ATRi reduces cGAS-mediated senescence and killing of MN-bearing cancer cells by natural killer cells.”

    Cells

    ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei

    Molecular cell

More on Cellular senescence

Micronuclei rupture

downin human cells1

1 study

  1. Atr inhibitors decrease micronuclei rupture in human cells.

    “In cells harboring MN, ATR or CDK1 inhibition reduces MN rupture.”

    Cells

    ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei

    Molecular cell

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