Asymmetric triplex metallohelix enantiomers

Asymmetric triplex metallohelix enantiomers decrease Aβ-induced toxicity in worms.

“attenuating Aβ-induced toxicity”

Model organismsin Caenorhabditis elegans CL2006

Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide

Science advances·19 Jan 2018

Asymmetric triplex metallohelix enantiomers extend lifespan in worms.

“Finally, an in vivo study showed that these metallohelices extend the life span of the Caenorhabditis elegans CL2006 strain by attenuating Aβ-induced toxicity.”

Model organismsin CL2006 strain

Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide

Science advances·19 Jan 2018