Asparagine

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 2 more
  • Model organisms1

Outcomes

4

Autophagy

upin model organisms1

1 study
  1. Asparagine activates autophagy.

    “Asn exerts its effects via the activation of the autophagic signaling pathway”

    Model organisms

    Asparagine prevents intestinal stem cell aging via the autophagy-lysosomal pathway

    Aging cell25 Nov 2024

More on Autophagy

Growth and branching of organoids

upin mouse cells1

1 study
  1. Asparagine increases growth and branching of organoids in mouse cells.

    “Asn promotes the growth and branching of elderly murine intestinal organoids”

    Cellsintestine

    Asparagine prevents intestinal stem cell aging via the autophagy-lysosomal pathway

    Aging cell25 Nov 2024

Lifespan

upin flies1

1 study
  1. Asparagine extends lifespan in flies.

    “maintains intestinal homeostasis, and extends the lifespan of aging flies”

    Model organisms

    Asparagine prevents intestinal stem cell aging via the autophagy-lysosomal pathway

    Aging cell25 Nov 2024

Intestinal stem cell hyperproliferation

downin flies1

1 study
  1. Asparagine decreases intestinal stem cell hyperproliferation in flies.

    “Asn inhibits the hyperproliferation of aging ISCs in Drosophila”

    Model organisms

    Asparagine prevents intestinal stem cell aging via the autophagy-lysosomal pathway

    Aging cell25 Nov 2024

Latest

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IUBMB Life

Plasma asparagine links to lower cardioembolic stroke risk

In Mendelian randomization, plasma free asparagine showed an odds ratio of 0.852 for cardioembolic stroke, whereas the glutamine-to-asparagine ratio yielded an odds ratio…In Mendelian randomization, plasma free asparagine showed an odds ratio of 0.852 for cardioembolic stroke, whereas the glutamine-to-asparagine ratio yielded an odds ratio of 1.148.

Mendelian randomisation in 8,299 peopleMechanisms