Anxa1− cd8+ naïve t cell transfer

Intervention

1 paper5 findings

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

5

Motor coordination

upin mice1

1 study
  1. Anxa1− cd8+ naïve t cell transfer improves motor coordination in mice.

    “improving cardiac function, bone density, motor coordination, and marrow immune microenvironment.”

    Animalssyngeneic ANXA1− CD8+ naïve T cellsmonthly transfer

    Transplanting ANXA1⁻ CD8⁺ Naïve T cells Delay Aging Through Senolysis

    bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2026Preprint

Cardiac function

upin mice1

1 study
  1. Anxa1− cd8+ naïve t cell transfer improves cardiac function in mice.

    “improving cardiac function, bone density, motor coordination, and marrow immune microenvironment.”

    Animalssyngeneic ANXA1− CD8+ naïve T cellsheartmonthly transfer

    Transplanting ANXA1⁻ CD8⁺ Naïve T cells Delay Aging Through Senolysis

    bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2026Preprint

Lifespan

upin mice1

1 study
  1. Anxa1− cd8+ naïve t cell transfer extends lifespan in mice (>30 weeks longer median lifespan).

    “Monthly transfer of syngeneic ANXA1− CD8+ naïve T cells into aged mice extended median lifespan by >30 weeks”

    Animalssyngeneic ANXA1− CD8+ naïve T cellsmonthly transfer

    Transplanting ANXA1⁻ CD8⁺ Naïve T cells Delay Aging Through Senolysis

    bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2026Preprint

Senescence burden

downin mice1

1 study
  1. Anxa1− cd8+ naïve t cell transfer decreases senescence burden in mice.

    “ANXA1− cells showed senolytic activity in vitro and reduced senescence burden in vivo”

    Animalsin vivo

    Transplanting ANXA1⁻ CD8⁺ Naïve T cells Delay Aging Through Senolysis

    bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2026Preprint

Senolysis

upin cells1

1 study
  1. Anxa1− cd8+ naïve t cell transfer induces senolysis in cells.

    “ANXA1− cells showed senolytic activity in vitro”

    Cellsin vitro

    Transplanting ANXA1⁻ CD8⁺ Naïve T cells Delay Aging Through Senolysis

    bioRxiv (Cold Spring Harbor Laboratory)23 Feb 2026Preprint

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 1Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 01 in 12 months