Antisense oligonucleotides targeting ggc

1 paper2 findings

1 lab in 1 country

Funders: First Affiliated Hospital of Zhengzhou University and 2 more

Cells1

Outcomes

2

polyG aggregation

downin human cells1

1 study

Antisense oligonucleotides targeting ggc decreases polyG aggregation in human cells.
“antisense oligonucleotides targeting GGC effectively reduce polyG aggregation and ameliorate related molecular defects”
Cellsin NIID patient-derived brain organoids
ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage, 3D chromatin structural abnormalities, and senescence
Nature communications7 Apr 2026

More on polyG aggregation

Cellular senescence

downin human cells1

1 study

Antisense oligonucleotides targeting ggc decreases cellular senescence in human cells.
“antisense oligonucleotides targeting GGC effectively reduce polyG aggregation and ameliorate related molecular defects, ultimately alleviating senescence-associated phenotypes.”
Cellsin NIID patient-derived brain organoids
ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage, 3D chromatin structural abnormalities, and senescence
Nature communications7 Apr 2026

More on Cellular senescence

Latest

1 in 12 months

Nature Communications7 Apr

ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage, 3D chromatin structural abnormalities, and senescence

Experiments in human cellsInterventions